negative control compounds Search Results


vtx-217 (a negative control with a similar core structure to other vtx compounds but with modifications to make inactive towards tlrs 7/8)  (VentiRx Pharmaceuticals Inc)
90
VentiRx Pharmaceuticals Inc vtx-217 (a negative control with a similar core structure to other vtx compounds but with modifications to make inactive towards tlrs 7/8)
(A) Seven TLR agonists were compared. (B) Representative structures of the TLR7/8 agonists used in this study. HEK-293 cells transfected with (C) human TLR7 and (D) TLR8 and an NF-κB-driven reporter SEAP gene were stimulated for 18–24 h with TLR agonists. The y-axis shows the level of SEAP activity in the Quanti-blue™ assay optical density (OD). The x-axis shows the concentration of each compound in µM. Each data point represents the mean ± SD of OD at 650 nm of triplicate culture wells. <t>VTX-217</t> (black) is a structurally matched negative control for VTX-744 (gray), VTX-087 (purple) and VTX-294 (red). The IMQ benchmarks R848 and CL075 are denoted in blue and green, respectively.
Vtx 217 (A Negative Control With A Similar Core Structure To Other Vtx Compounds But With Modifications To Make Inactive Towards Tlrs 7/8), supplied by VentiRx Pharmaceuticals Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/vtx-217 (a negative control with a similar core structure to other vtx compounds but with modifications to make inactive towards tlrs 7/8)/product/VentiRx Pharmaceuticals Inc
Average 90 stars, based on 1 article reviews
vtx-217 (a negative control with a similar core structure to other vtx compounds but with modifications to make inactive towards tlrs 7/8) - by Bioz Stars, 2026-04
90/100 stars
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negative control compound 4  (Eurofins)
90
Eurofins negative control compound 4
(A) Seven TLR agonists were compared. (B) Representative structures of the TLR7/8 agonists used in this study. HEK-293 cells transfected with (C) human TLR7 and (D) TLR8 and an NF-κB-driven reporter SEAP gene were stimulated for 18–24 h with TLR agonists. The y-axis shows the level of SEAP activity in the Quanti-blue™ assay optical density (OD). The x-axis shows the concentration of each compound in µM. Each data point represents the mean ± SD of OD at 650 nm of triplicate culture wells. <t>VTX-217</t> (black) is a structurally matched negative control for VTX-744 (gray), VTX-087 (purple) and VTX-294 (red). The IMQ benchmarks R848 and CL075 are denoted in blue and green, respectively.
Negative Control Compound 4, supplied by Eurofins, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/negative control compound 4/product/Eurofins
Average 90 stars, based on 1 article reviews
negative control compound 4 - by Bioz Stars, 2026-04
90/100 stars
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negative control compound tx2-135-2  (Verlag GmbH)
90
Verlag GmbH negative control compound tx2-135-2
(A) Seven TLR agonists were compared. (B) Representative structures of the TLR7/8 agonists used in this study. HEK-293 cells transfected with (C) human TLR7 and (D) TLR8 and an NF-κB-driven reporter SEAP gene were stimulated for 18–24 h with TLR agonists. The y-axis shows the level of SEAP activity in the Quanti-blue™ assay optical density (OD). The x-axis shows the concentration of each compound in µM. Each data point represents the mean ± SD of OD at 650 nm of triplicate culture wells. <t>VTX-217</t> (black) is a structurally matched negative control for VTX-744 (gray), VTX-087 (purple) and VTX-294 (red). The IMQ benchmarks R848 and CL075 are denoted in blue and green, respectively.
Negative Control Compound Tx2 135 2, supplied by Verlag GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/negative control compound tx2-135-2/product/Verlag GmbH
Average 90 stars, based on 1 article reviews
negative control compound tx2-135-2 - by Bioz Stars, 2026-04
90/100 stars
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Image Search Results


(A) Seven TLR agonists were compared. (B) Representative structures of the TLR7/8 agonists used in this study. HEK-293 cells transfected with (C) human TLR7 and (D) TLR8 and an NF-κB-driven reporter SEAP gene were stimulated for 18–24 h with TLR agonists. The y-axis shows the level of SEAP activity in the Quanti-blue™ assay optical density (OD). The x-axis shows the concentration of each compound in µM. Each data point represents the mean ± SD of OD at 650 nm of triplicate culture wells. VTX-217 (black) is a structurally matched negative control for VTX-744 (gray), VTX-087 (purple) and VTX-294 (red). The IMQ benchmarks R848 and CL075 are denoted in blue and green, respectively.

Journal: PLoS ONE

Article Title: The Ultra-Potent and Selective TLR8 Agonist VTX-294 Activates Human Newborn and Adult Leukocytes

doi: 10.1371/journal.pone.0058164

Figure Lengend Snippet: (A) Seven TLR agonists were compared. (B) Representative structures of the TLR7/8 agonists used in this study. HEK-293 cells transfected with (C) human TLR7 and (D) TLR8 and an NF-κB-driven reporter SEAP gene were stimulated for 18–24 h with TLR agonists. The y-axis shows the level of SEAP activity in the Quanti-blue™ assay optical density (OD). The x-axis shows the concentration of each compound in µM. Each data point represents the mean ± SD of OD at 650 nm of triplicate culture wells. VTX-217 (black) is a structurally matched negative control for VTX-744 (gray), VTX-087 (purple) and VTX-294 (red). The IMQ benchmarks R848 and CL075 are denoted in blue and green, respectively.

Article Snippet: VTX-217 (a negative control with a similar core structure to other VTX compounds but with modifications to make inactive towards TLRs 7/8), VTX-744 (TLR8), VTX-087 (TLR8) and VTX-294 (TLR8) (VentiRx Pharmaceuticals, Inc., Seattle, WA, USA) were produced using a method of synthesis of substituted benzazepine derivatives .

Techniques: Transfection, Activity Assay, Concentration Assay, Negative Control